Effects of Oxygenated Carotenoid β-Cryptoxanthin on Morphological Differentiation and Apoptosis in Neuro2a Neuroblastoma Cells

Satoko NOGUCHI; Takashi SUMIDA; Hiroshi OGAWA; Mikiro TADA; Kyoya TAKAHATA

doi:10.1271/bbb.67.2467

Food & Nutrition Science Notes

Effects of Oxygenated Carotenoid β-Cryptoxanthin on Morphological Differentiation and Apoptosis in Neuro2a Neuroblastoma Cells

Satoko NOGUCHI, Takashi SUMIDA, Hiroshi OGAWA, Mikiro TADA, Kyoya TAKAHATA

Author information

Keywords: β-cryptoxanthin, Neuro2a cells, neurite, caspase-3, apoptosis

JOURNAL FREE ACCESS

2003 Volume 67 Issue 11 Pages 2467-2469

DOI https://doi.org/10.1271/bbb.67.2467

Details

Abstract

Beta-Cryptoxanthin (βCx) was investigated for cell functions in neuroblastoma Neuro2a cells. The following results were obtained. 1. Beta-Cx induced neurite outgrowth. 2. Beta-Cx inhibited the etoposide-induced activation of caspase-3 activity in a dose-dependent manner. These data suggest a bioregulatry function of βCx in the control of differentiation and apoptosis in Neuro2a cells.

Corresponding author

Register with J-STAGE for free!