Suppression of Dioxin Mediated Aryl Hydrocarbon Receptor Transformation by Ethanolic Extracts of Propolis

Yong K. PARK; Itsuko FUKUDA; Hitoshi ASHIDA; Shin NISHIUMI; Julio Paredes GUZMAN; Helia H. SATO; Glaucia M. PASTORE

doi:10.1271/bbb.68.935

Biochemistry & Molecular Biology Notes

Suppression of Dioxin Mediated Aryl Hydrocarbon Receptor Transformation by Ethanolic Extracts of Propolis

Yong K. PARK, Itsuko FUKUDA, Hitoshi ASHIDA, Shin NISHIUMI, Julio Paredes GUZMAN, Helia H. SATO, Glaucia M. PASTORE

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Keywords: propolis, flavonoids, aryl hydrocarbon receptor, dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

JOURNAL FREE ACCESS

2004 Volume 68 Issue 4 Pages 935-938

DOI https://doi.org/10.1271/bbb.68.935

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Abstract

Present study demonstrated that the ethanolic extracts of propolis containing higher concentrations of flavonoids suppressed 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor transformation in a dose-dependent manner. The IC₅₀ values of propolis group 3 and group 12 were 1.2 and 3.6 μg/ml, respectively, indicating that propolis showed stronger antagonistic effects as compared with vegetable extracts.

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