Inhibition of Osteoporosis Induced by Protein Deficient (PD) Food Intake by Active Vitamin D3 and Vitamin K2 in Rats

Liman SUN; Hajime TAMAKI; Yutaka OHTA; Naofumi KATSUYAMA; Tetsuji ISHIMARU; Isao CHINEN

doi:10.1271/bbb.68.1385

Food & Nutrition Science Notes

Inhibition of Osteoporosis Induced by Protein Deficient (PD) Food Intake by Active Vitamin D₃ and Vitamin K₂ in Rats

Liman SUN, Hajime TAMAKI, Yutaka OHTA, Naofumi KATSUYAMA, Tetsuji ISHIMARU, Isao CHINEN

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Keywords: osteoporosis, protein deficient food, active vitamin D₃, vitamin K₂, alkaline phosphatase

JOURNAL FREE ACCESS

2004 Volume 68 Issue 6 Pages 1385-1387

DOI https://doi.org/10.1271/bbb.68.1385

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Abstract

Independent use of K₂ and D₃ and simultaneous application of K₂ and D₃ inhibited the development of osteoporosis caused by PD food intake. The ALP activity of urine as a marker of bone formation osteoporosis did not rise in rats fed PD foods containing D₃, K₂ or both together. Body and womb weights fell in rats fed PD foods with D₃ K₂ and both D₃, K₂. Osteoporosis caused by PD food intake found to be very similar to type II osteoporosis in respects of inhibition by D₃ and K₂ and rising urinary ALP activity.

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