Mitogenic Properties of Pokeweed Lectin-D Isoforms on Human Peripheral Blood Lymphocytes: Non-mitogen PL-D1 and Mitogen PL-D2

Kenichi YAMAGUCHI; Mizuki UECHI; Yoshinori KATAKURA; Tatsuya ODA; Masatsune ISHIGURO

doi:10.1271/bbb.68.1591

Biochemistry & Molecular Biology Notes

Mitogenic Properties of Pokeweed Lectin-D Isoforms on Human Peripheral Blood Lymphocytes: Non-mitogen PL-D1 and Mitogen PL-D2

Kenichi YAMAGUCHI, Mizuki UECHI, Yoshinori KATAKURA, Tatsuya ODA, Masatsune ISHIGURO

著者情報

キーワード: pokeweed mitogen, chitin-binding lectin, hevein domain, Phytolacca americana

ジャーナルフリー

2004 年 68 巻 7 号 p. 1591-1593

DOI https://doi.org/10.1271/bbb.68.1591

詳細

抄録

We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.

責任著者(Corresponding author)

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