Y-700, a Novel Inhibitor of Xanthine Oxidase, Suppresses the Development of Colon Aberrant Crypt Foci and Cell Proliferation in 1,2-Dimethylhydrazine-Treated Mice

Takao HASHIMOTO; Atsushi FUKUNARI; Ichimaro YAMADA; Noriyuki YANAKA; Dong CHEN; Norihisa KATO

doi:10.1271/bbb.69.209

Biochemistry & Molecular Biology Notes

Y-700, a Novel Inhibitor of Xanthine Oxidase, Suppresses the Development of Colon Aberrant Crypt Foci and Cell Proliferation in 1,2-Dimethylhydrazine-Treated Mice

Takao HASHIMOTO, Atsushi FUKUNARI, Ichimaro YAMADA, Noriyuki YANAKA, Dong CHEN, Norihisa KATO

著者情報

キーワード: colon aberrant crypt foci, xanthine oxidase, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid (Y-700), reactive oxygen species, cell proliferation

ジャーナルフリー

2005 年 69 巻 1 号 p. 209-211

DOI https://doi.org/10.1271/bbb.69.209

詳細

抄録

Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.

責任著者(Corresponding author)

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