Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
The Necessity of Niacin in Rats Fed on a High Protein Diet
Naoko KIMURATsutomu FUKUWATARIRyuzo SASAKIKatsumi SHIBATA
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JOURNAL FREE ACCESS

2005 Volume 69 Issue 2 Pages 273-279

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Abstract

It is known that niacin itself is not necessary in rats when tryptophan is given in adequate amounts, because rats can biosynthesize niacin from tryptophan. In our experiment, young rats were fed on a 20%, 40%, 60%, or 70% casein diet with or without niacin. The rats fed on the 20%, 40%, and 60% casein diets did not require niacin for growth, but the rats fed on the 70% casein diet needed it. This phenomenon was attributed to the supposition that liver aminocarboxymuconate–semialdehyde decarboxylase activities increased according with the dietary casein levels. The conversion ratio of tryptophan–niacin in rats fed on the 70% casein diet became extremely low, and then the rats needed niacin.

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© 2005 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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