Biosynthetic Origin of the Carbon Skeleton and Nitrogen Atom of Pamamycin-607, a Nitrogen-Containing Polyketide

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The biosynthesis of pamamycin-607 (PM-607), a sixteen-membered macrodiolide compound, was studied with ¹³C- and ¹⁵N-labeled precursor units in Streptomyces alboniger. Feeding experiments with ¹³C-labeled acetate or propionate indicate that the carbon skeleton of PM-607 was derived from six acetate, four propionate and three succinate units. MS analyses of ¹⁵N-labeled PM-607 suggest that the nitrogen atom in PM-607 was derived from the α-amino group of an amino acid.