Synthesis of D-Allose Fatty Acid Esters via Lipase-Catalyzed Regioselective Transesterification

Abstract

The acylation of the rare sugar, D-allose (the C-3 epimer of D-glucose), with fatty acid vinyl esters was successfully carried out using Candida antarctica lipase in acetonitrile at 45 °C to give D-allose 6-alkanoates with high regioselectivity in good yields.