Synthesis of a Methylene Analog of 5-Amino-1-β-<small>D</small>-ribofuranosylimidazole-4-carboxamide Monophosphate (ZMP)

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Notes

Synthesis of a Methylene Analog of 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide Monophosphate (ZMP)

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Keywords: AMPK, AICAR, ZMP, inosine, monophosphate

JOURNAL FREE ACCESS

2005 Volume 69 Issue 4 Pages 836-838

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Abstract

A novel ZMP analog 3 was synthesized from inosine in 10 steps, and exhibited small but significant inhibitory activity toward protein kinase C.

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