Prolyl Endopeptidase and Thrombin Inhibitory Diterpenoids from the Bark of Xylopia aethiopica

Noungoue Tchamo DIDEROT; Ngouela SILVERE; Amsha YASIN; Seema ZAREEN; Zelefack FABIEN; Tsamo ETIENNE; M. Iqbal CHOUDHARY; ATTA-UR-RAHMAN

doi:10.1271/bbb.69.1763

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Note

Prolyl Endopeptidase and Thrombin Inhibitory Diterpenoids from the Bark of Xylopia aethiopica

Noungoue Tchamo DIDEROT, Ngouela SILVERE, Amsha YASIN, Seema ZAREEN, Zelefack FABIEN, Tsamo ETIENNE, M. Iqbal CHOUDHARY, ATTA-UR-RAHMAN

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Keywords: Xylopia aethiopica, diterpene, prolyl endopeptidase, thrombin, enzyme inhibition

JOURNAL FREE ACCESS

2005 Volume 69 Issue 9 Pages 1763-1766

DOI https://doi.org/10.1271/bbb.69.1763

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Abstract

The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and α-thrombin. Five compounds exhibited inhibitory activity against them.

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