Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice

Ryoko OHNISHI; Hideyuki ITO; Ayumu IGUCHI; Kazuaki SHINOMIYA; Chiaki KAMEI; Tsutomu HATANO; Takashi YOSHIDA

doi:10.1271/bbb.60243

Food & Nutrition Science Notes

Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice

Ryoko OHNISHI, Hideyuki ITO, Ayumu IGUCHI, Kazuaki SHINOMIYA, Chiaki KAMEI, Tsutomu HATANO, Takashi YOSHIDA

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Keywords: chlorogenic acid, microbial metabolite, caffeic acid, spontaneous locomotor activity, psychostimulant activity

JOURNAL FREE ACCESS

2006 Volume 70 Issue 10 Pages 2560-2563

DOI https://doi.org/10.1271/bbb.60243

View "Advance Publication" version (October 7, 2006).

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Abstract

Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.

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