Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
A Role of a Lymphocyte Tryptase, Granzyme A, in Experimental Ulcerative Colitis
Hirofumi HIRAYASUYumiko YOSHIKAWASatoshi TSUZUKITohru FUSHIKI
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JOURNAL FREE ACCESS

2007 Volume 71 Issue 1 Pages 234-237

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Abstract

In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis.

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© 2007 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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