A Role of a Lymphocyte Tryptase, Granzyme A, in Experimental Ulcerative Colitis

Hirofumi HIRAYASU; Yumiko YOSHIKAWA; Satoshi TSUZUKI; Tohru FUSHIKI

doi:10.1271/bbb.60354

This article has now been updated. Please use the final version.

A Role of a Lymphocyte Tryptase, Granzyme A, in Experimental Ulcerative Colitis

Hirofumi HIRAYASU, Yumiko YOSHIKAWA, Satoshi TSUZUKI, Tohru FUSHIKI

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Keywords: granzyme A, cytotoxic T-lymphocytes, ulcerative colitis, dextran sulfate sodium, pancreatic secretory trypsin inhibitor

JOURNAL FREE ACCESS Advance online publication

Article ID: 60354

DOI https://doi.org/10.1271/bbb.60354

The final version of this article is now available: Vol. 71 (2007) , No. 1 p.234

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Abstract

In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis.

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