Poecillastrin D: A New Cytotoxin of the Chondropsin Class from Marine Sponge Jaspis serpentina

Daisaku TAKEMOTO; Yoshihiko TAKEKAWA; Rob W. M. van SOEST; Nobuhiro FUSETANI; Shigeki MATSUNAGA

doi:10.1271/bbb.70293

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Regular Papers

Poecillastrin D: A New Cytotoxin of the Chondropsin Class from Marine Sponge Jaspis serpentina

Daisaku TAKEMOTO, Yoshihiko TAKEKAWA, Rob W. M. van SOEST, Nobuhiro FUSETANI, Shigeki MATSUNAGA

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Keywords: cytotoxic metabolite, marine sponge, macrolide lactam

JOURNAL FREE ACCESS

2007 Volume 71 Issue 11 Pages 2697-2700

DOI https://doi.org/10.1271/bbb.70293

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Abstract

Poecillastrin D (2) was isolated together with poecillastrin C (1) from the deep sea sponge, Japsis serpentina. Its structure was elucidated to be that of a macrolide lactam by spectroscopic methods. These compounds showed potent cytotoxicity against various tumor cell lines.

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