Poecillastrin D: A New Cytotoxin of the Chondropsin Class from Marine Sponge Jaspis serpentina

Daisaku TAKEMOTO; Yoshihiko TAKEKAWA; Rob van SOEST; Nobuhiro FUSETANI; Shigeki MATSUNAGA

doi:10.1271/bbb.70293

This article has now been updated. Please use the final version.

Poecillastrin D: A New Cytotoxin of the Chondropsin Class from Marine Sponge Jaspis serpentina

Daisaku TAKEMOTO, Yoshihiko TAKEKAWA, Rob van SOEST, Nobuhiro FUSETANI, Shigeki MATSUNAGA

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Keywords: cytotoxic metabolite, marine sponge, macrolide lactam

JOURNAL FREE ACCESS Advance online publication

Article ID: 70293

DOI https://doi.org/10.1271/bbb.70293

The final version of this article is now available: Vol. 71 (2007) , No. 11 p.2697

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Abstract

Poecillastrin D (2) was isolated together with poecillastrin C (1) from the deep sea sponge, Japsis serpentina. Its structure was elucidated to be that of a macrolide lactam by spectroscopic methods. These compounds showed potent cytotoxicity against various tumor cell lines.

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