Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Effects of a Hop Water Extract on the Compound 48/80-Stimulated Vascular Permeability in ICR Mice and Histamine Release from OVA-Sensitized BALB/c Mice
Shuichi SEGAWAYoshihiro TAKATAHirotaka KANEDAJunji WATARI
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JOURNAL FREE ACCESS

2007 Volume 71 Issue 6 Pages 1577-1581

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Abstract

The antiallergic properties of a hop water extract (HWE) were studied by evaluating the Evans blue leakage from ICR mice caused by compound 48/80 stimulation, and the histamine release from ovalbumin (OVA)-sensitized BALB/c mice. An oral administration of HWE significantly inhibited the vascular permeability and histamine release. HWE itself did not have any influence on the total and antigen-specific immunoglobulin E (IgE) production in OVA-sensitized mice. These results indicate that HWE exerted an antiallergic effect by inhibiting the release of chemical mediators from mast cells and basophiles.

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© 2007 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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