Soy Isoflavone Aglycone Modulates Expression of Cell Surface Antigens in Vitro and in Vivo

Toshie HARADA; Masayuki ARII; Ryohei F. TSUJI; Yoshiyuki ADACHI; Mitsuhiro NAKAJIMA; Toshiro YADOMAE; Naohito OHNO

doi:10.1271/bbb.70040

Food & Nutrition Science Notes

Soy Isoflavone Aglycone Modulates Expression of Cell Surface Antigens in Vitro and in Vivo

Toshie HARADA, Masayuki ARII, Ryohei F. TSUJI, Yoshiyuki ADACHI, Mitsuhiro NAKAJIMA, Toshiro YADOMAE, Naohito OHNO

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Keywords: soy isoflavone aglycone, myeloid cell, CD80, CD86

JOURNAL FREE ACCESS

2007 Volume 71 Issue 7 Pages 1769-1772

DOI https://doi.org/10.1271/bbb.70040

View "Advance Publication" version (July 7, 2007).

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Abstract

Soy isoflavone aglycones (IFAs) have a wide range of biological actions. We investigated in this study the effect of IFAs on myeloid cells. The cell surface expression of both CD80 and CD86 was up-regulated by treating myeloid cells with IFAs in vitro and in vivo. The findings suggest that IFAs could modulate the myeloid cell function.

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