Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Masaya SHIMADA; Kazuki MOCHIZUKI; Naoko SAKURAI; Toshinao GODA

doi:10.1271/bbb.70174

Food & Nutrition Science Notes

Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Masaya SHIMADA, Kazuki MOCHIZUKI, Naoko SAKURAI, Toshinao GODA

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Keywords: adiponectin, epigallocatechin gallate (EGCG), Goto-Kakizaki (GK) rats, insulin secretory dysfunction

JOURNAL FREE ACCESS

2007 Volume 71 Issue 8 Pages 2079-2082

DOI https://doi.org/10.1271/bbb.70174

View "Advance Publication" version (August 7, 2007).

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Abstract

Epigallocatechin gallate (EGCG) reportedly enhances plasma adiponectin levels in models of insulin resistance and obesity. In this study, we found that EGCG increases plasma adiponectin levels and decreases plasma triacylglycerol levels in non-obese diabetic Goto-Kakizaki rats with insulin secretory dysfunction. These results suggest that EGCG ameliorates lipid metabolic abnormality even in non-obese rats, probably by increasing adiponectin production.

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