Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Masaya SHIMADA; Kazuki MOCHIZUKI; Naoko SAKURAI; Toshinao GODA

doi:10.1271/bbb.70174

This article has now been updated. Please use the final version.

Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Masaya SHIMADA, Kazuki MOCHIZUKI, Naoko SAKURAI, Toshinao GODA

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Keywords: adiponectin, epigallocatechin gallate (EGCG), Goto-Kakizaki (GK) rats, insulin secretory dysfunction

JOURNAL FREE ACCESS Advance online publication

Article ID: 70174

DOI https://doi.org/10.1271/bbb.70174

The final version of this article is now available: Vol. 71 (2007) , No. 8 p.2079

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Abstract

Epigallocatechin gallate (EGCG) reportedly enhances plasma adiponectin levels in models of insulin resistance and obesity. In this study, we found that EGCG increases plasma adiponectin levels and decreases plasma triacylglycerol levels in non-obese diabetic Goto-Kakizaki rats with insulin secretory dysfunction. These results suggest that EGCG ameliorates lipid metabolic abnormality even in non-obese rats, probably by increasing adiponectin production.

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