Dillapiol and Apiol as Specific Inhibitors of the Biosynthesis of Aflatoxin G1 in Aspergillus parasiticus

Mehdi RAZZAGHI-ABYANEH; Tomoya YOSHINARI; Masoomeh SHAMS-GHAHFAROKHI; Mohammad-Bagher REZAEE; Hiromichi NAGASAWA; Shohei SAKUDA

doi:10.1271/bbb.70264

Organic Chemistry Notes

Dillapiol and Apiol as Specific Inhibitors of the Biosynthesis of Aflatoxin G₁ in Aspergillus parasiticus

Mehdi RAZZAGHI-ABYANEH, Tomoya YOSHINARI, Masoomeh SHAMS-GHAHFAROKHI, Mohammad-Bagher REZAEE, Hiromichi NAGASAWA, Shohei SAKUDA

著者情報

キーワード: aflatoxin, Aspergillus parasiticus, dillapiol, apiol, inhibitor

ジャーナルフリー

2007 年 71 巻 9 号 p. 2329-2332

DOI https://doi.org/10.1271/bbb.70264

View "Advance Publication" version (September 7, 2007).

詳細

抄録

Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin G₁ production. It inhibited aflatoxin G₁ production by Aspergillus parasiticus with an IC₅₀ value of 0.15 μM without inhibiting aflatoxin B₁ production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with IC₅₀ values of 0.24 and 3.5 μM, respectively.

責任著者(Corresponding author)

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