Effect of Bovine Lactoferrin on Extracellular Matrix Calcification by Human Osteoblast-Like Cells

Yoshiharu TAKAYAMA; Koko MIZUMACHI

doi:10.1271/bbb.70465

Food & Nutrition Science Notes

Effect of Bovine Lactoferrin on Extracellular Matrix Calcification by Human Osteoblast-Like Cells

Yoshiharu TAKAYAMA, Koko MIZUMACHI

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Keywords: alkaline phosphatase, calcium deposition, osteocalcin, osteogenesis, MG63 cells

JOURNAL FREE ACCESS

2008 Volume 72 Issue 1 Pages 226-230

DOI https://doi.org/10.1271/bbb.70465

View "Advance Publication" version (January 7, 2008).

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Abstract

Osteoblast-mediated calcium deposition to the extracellular matrix (ECM) is a critical step in bone tissue generation. Bovine lactoferrin enhanced the calcium deposition by MG63 human osteoblast-like cells cultured on collagen-coated plates. Lactoferrin also promoted the alkaline phosphatase activity and osteocalcin production during the calcification process, whereas it had little effect on the growth of the cells on the collagen-coated plates.

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