Effect of Bovine Lactoferrin on Extracellular Matrix Calcification by Human Osteoblast-Like Cells

Yoshiharu TAKAYAMA; Koko MIZUMACHI

doi:10.1271/bbb.70465

This article has now been updated. Please use the final version.

Effect of Bovine Lactoferrin on Extracellular Matrix Calcification by Human Osteoblast-Like Cells

Yoshiharu TAKAYAMA, Koko MIZUMACHI

Author information

Keywords: alkaline phosphatase, calcium deposition, osteocalcin, osteogenesis, MG63 cells

JOURNAL FREE ACCESS Advance online publication

Article ID: 70465

DOI https://doi.org/10.1271/bbb.70465

The final version of this article is now available: Vol. 72 (2008) , No. 1 p.226

Details

Abstract

Osteoblast-mediated calcium deposition to the extracellular matrix (ECM) is a critical step in bone tissue generation. Bovine lactoferrin enhanced the calcium deposition by MG63 human osteoblast-like cells cultured on collagen-coated plates. Lactoferrin also promoted the alkaline phosphatase activity and osteocalcin production during the calcification process, whereas it had little effect on the growth of the cells on the collagen-coated plates.

Corresponding author

Register with J-STAGE for free!