Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

Toshiro NOSHITA; Shinji FUNAYAMA; Tadayoshi HIRAKAWA; Yumi KIDACHI; Kazuo RYOYAMA

doi:10.1271/bbb.80327

Organic Chemistry Notes

Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

Toshiro NOSHITA, Shinji FUNAYAMA, Tadayoshi HIRAKAWA, Yumi KIDACHI, Kazuo RYOYAMA

著者情報

キーワード: Magnolia denudata, machilin G, denudatin, nitric oxide synthase, macrophage

ジャーナルフリー

2008 年 72 巻 10 号 p. 2775-2778

DOI https://doi.org/10.1271/bbb.80327

View "Advance Publication" version (October 7, 2008).

詳細

抄録

Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-γ activated-murine macrophage cell line, J774.1. Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.

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