Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

Toshiro NOSHITA; Shinji FUNAYAMA; Tadayoshi HIRAKAWA; Yumi KIDACHI; Kazuo RYOYAMA

doi:10.1271/bbb.80327

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Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

Toshiro NOSHITA, Shinji FUNAYAMA, Tadayoshi HIRAKAWA, Yumi KIDACHI, Kazuo RYOYAMA

著者情報

キーワード: Magnolia denudata, machilin G, denudatin, nitric oxide synthase, macrophage

ジャーナルフリー早期公開

論文ID: 80327

DOI https://doi.org/10.1271/bbb.80327

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 10 p.2775

詳細

抄録

Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-γ activated-murine macrophage cell line, J774.1. Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.

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