Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

Yuuki SATO; Hiroshi KAMIYAMA; Takeo USUI; Tamio SAITO; Hiroyuki OSADA; Shigefumi KUWAHARA; Hiromasa KIYOTA

doi:10.1271/bbb.80562

Organic Chemistry Regular Papers

Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

Yuuki SATO, Hiroshi KAMIYAMA, Takeo USUI, Tamio SAITO, Hiroyuki OSADA, Shigefumi KUWAHARA, Hiromasa KIYOTA

著者情報

キーワード: Cortisium simplex, cortistatin A, synthesis, HUVEC, angiogenesis

ジャーナルフリー

2008 年 72 巻 11 号 p. 2992-2997

DOI https://doi.org/10.1271/bbb.80562

View "Advance Publication" version (November 7, 2008).

詳細

抄録

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

責任著者(Corresponding author)

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