Synthetic Studies on Kohamaic Acids: Synthesis of Structurally Simplified Analogs of Kohamaic Acid A

Hirosato TAKIKAWA; Naoki KAMATANI; Kohei NAKANISHI; Takuya TASHIRO; Mitsuru SASAKI; Hiromi YOSHIDA; Yoshiyuki MIZUSHINA

doi:10.1271/bbb.80629

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Communication

Synthetic Studies on Kohamaic Acids: Synthesis of Structurally Simplified Analogs of Kohamaic Acid A

Hirosato TAKIKAWA, Naoki KAMATANI, Kohei NAKANISHI, Takuya TASHIRO, Mitsuru SASAKI, Hiromi YOSHIDA, Yoshiyuki MIZUSHINA

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Keywords: kohamaic acid, DNA polymerase, sesterterpene, synthetic analogs

JOURNAL FREE ACCESS

2008 Volume 72 Issue 11 Pages 3071-3074

DOI https://doi.org/10.1271/bbb.80629

View "Advance Publication" version (November 7, 2008).

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Abstract

Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.

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