Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide

Satoshi UENO; Kohtaro KUSAKA; Yasushi TAMADA; Masaomi MINABA; Hong ZHANG; Pi-Chao WANG; Yusuke KATO

doi:10.1271/bbb.80397

Biochemistry & Molecular Biology Notes

Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide

Satoshi UENO, Kohtaro KUSAKA, Yasushi TAMADA, Masaomi MINABA, Hong ZHANG, Pi-Chao WANG, Yusuke KATO

著者情報

キーワード: cecropin, antimicrobial peptide, precursor, innate immunity, nematode

ジャーナルフリー

2008 年 72 巻 12 号 p. 3281-3284

DOI https://doi.org/10.1271/bbb.80397

View "Advance Publication" version (December 7, 2008).

詳細

抄録

Recently, an anionic proregion was found to be conserved at the C terminus of the antimicrobial peptide, nematode cecropin. Our results suggest that the antimicrobial activity of mature peptide is suppressed by the proregion in its precursor and is released from inhibition after processing. Inhibition is not likely to be due to direct suppression of membrane disruption.

責任著者(Corresponding author)

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