Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide

Satoshi UENO; Kohtaro KUSAKA; Yasushi TAMADA; Masaomi MINABA; Hong ZHANG; Pi-Chao WANG; Yusuke KATO

doi:10.1271/bbb.80397

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide

Satoshi UENO, Kohtaro KUSAKA, Yasushi TAMADA, Masaomi MINABA, Hong ZHANG, Pi-Chao WANG, Yusuke KATO

著者情報

キーワード: cecropin, antimicrobial peptide, precursor, innate immunity, nematode

ジャーナルフリー早期公開

論文ID: 80397

DOI https://doi.org/10.1271/bbb.80397

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 12 p.3281

詳細

抄録

Recently, an anionic proregion was found to be conserved at the C terminus of the antimicrobial peptide, nematode cecropin. Our results suggest that the antimicrobial activity of mature peptide is suppressed by the proregion in its precursor and is released from inhibition after processing. Inhibition is not likely to be due to direct suppression of membrane disruption.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）