Possible Involvement of Prolactin in the Synthesis of Lactoferrin in Bovine Mammary Epithelial Cells

Kei-ichi NAKAJIMA; Masato NAKAMURA; Xiao-Dong GAO; Takaharu KOZAKAI

doi:10.1271/bbb.70713

Biochemistry & Molecular Biology Notes

Possible Involvement of Prolactin in the Synthesis of Lactoferrin in Bovine Mammary Epithelial Cells

Kei-ichi NAKAJIMA, Masato NAKAMURA, Xiao-Dong GAO, Takaharu KOZAKAI

著者情報

キーワード: lactoferrin, prolactin, mammary epithelial cells, bovine

ジャーナルフリー

2008 年 72 巻 4 号 p. 1103-1106

DOI https://doi.org/10.1271/bbb.70713

View "Advance Publication" version (April 7, 2008).

詳細

抄録

Bovine mammary epithelial cells (bMECs) synthesize lactoferrin, which is secreted into milk. Our results suggest that prolactin stimulated secretion of lactoferrin in primary bMECs and their clonal cell line under serum-free conditions. Prolactin also stimulated mRNA expression of lactoferrin in the clonal cell line. This effect was reduced by AG-490, suggesting that the prolactin-stimulated mRNA expression of lactoferrin was mediated by Janus kinase (JAK)2.

責任著者(Corresponding author)

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