Asymmetric Reduction of Benzil to (S)-Benzoin with Penicillium claviforme IAM 7294 in a Liquid-Liquid Interface Bioreactor (L-L IBR)

Shinobu ODA; Kunio ISSHIKI

doi:10.1271/bbb.70729

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Microbiology & Fermentation Technology Notes

Asymmetric Reduction of Benzil to (S)-Benzoin with Penicillium claviforme IAM 7294 in a Liquid-Liquid Interface Bioreactor (L-L IBR)

Shinobu ODA, Kunio ISSHIKI

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Keywords: Penicillium, benzoin, liquid-surface cultivation, interface bioreactor, asymmetric reduction

JOURNAL FREE ACCESS

2008 Volume 72 Issue 5 Pages 1364-1367

DOI https://doi.org/10.1271/bbb.70729

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Abstract

The asymmetric reduction of benzyl to (S)-benzoin with Penicillium claviforme IAM 7294 was applied to a liquid-liquid interface bioreactor (L-L IBR) using a unique polymeric material, ballooned microsphere (MS). The L-L IBR showed superior performance, as compared with suspension, organic-aqueous two-liquid-phase, and solid-liquid interface bioreactor (S-L IBR) systems, affording 14.4 g/l-organic phase of (S)-benzoin (99.0% ee).

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