Interaction of the Molecular Chaperone HtpG with Uroporphyrinogen Decarboxylase in the Cyanobacterium Synechococcus elongatus PCC 7942

Masakazu SAITO; Satoru WATANABE; Hirofumi YOSHIKAWA; Hitoshi NAKAMOTO

doi:10.1271/bbb.80093

Microbiology & Fermentation Technology Notes

Interaction of the Molecular Chaperone HtpG with Uroporphyrinogen Decarboxylase in the Cyanobacterium Synechococcus elongatus PCC 7942

Masakazu SAITO, Satoru WATANABE, Hirofumi YOSHIKAWA, Hitoshi NAKAMOTO

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Keywords: cyanobacterium, Hsp90, HtpG, tetrapyrrole, uroporphyrinogen decarboxylase

JOURNAL FREE ACCESS

2008 Volume 72 Issue 5 Pages 1394-1397

DOI https://doi.org/10.1271/bbb.80093

View "Advance Publication" version (May 7, 2008).

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Abstract

Uroporphyrinogen decarboxylase (HemE) is important due to its location at the first branch-point in tetrapyrrole biosynthesis. We detected a complex formation between full-length polypeptides of HtpG and HemE by biochemical studies in vivo and in vitro. The interaction suppressed the enzyme activity, suggesting a regulatory role of HtpG in tetrapyrrole biosynthesis.

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