Interaction of the Molecular Chaperone HtpG with Uroporphyrinogen Decarboxylase in the Cyanobacterium Synechococcus elongatus PCC 7942

Masakazu SAITO; Satoru WATANABE; Hirofumi YOSHIKAWA; Hitoshi NAKAMOTO

doi:10.1271/bbb.80093

This article has now been updated. Please use the final version.

Interaction of the Molecular Chaperone HtpG with Uroporphyrinogen Decarboxylase in the Cyanobacterium Synechococcus elongatus PCC 7942

Masakazu SAITO, Satoru WATANABE, Hirofumi YOSHIKAWA, Hitoshi NAKAMOTO

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Keywords: cyanobacterium, Hsp90, HtpG, tetrapyrrole, uroporphyrinogen decarboxylase

JOURNAL FREE ACCESS Advance online publication

Article ID: 80093

DOI https://doi.org/10.1271/bbb.80093

The final version of this article is now available: Vol. 72 (2008) , No. 5 p.1394

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Abstract

Uroporphyrinogen decarboxylase (HemE) is important due to its location at the first branch-point in tetrapyrrole biosynthesis. We detected a complex formation between full-length polypeptides of HtpG and HemE by biochemical studies in vivo and in vitro. The interaction suppressed the enzyme activity, suggesting a regulatory role of HtpG in tetrapyrrole biosynthesis.

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