Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Microbiology & Fermentation Technology Notes
Inhibition of Pathogen Adhesion to Host Cells by Polysaccharides from Panax ginseng
Ji-Hye LEEJin Sun SHIMMi-Sook CHUNGSeung-Taik LIMKyung Hyun KIM
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2009 年 73 巻 1 号 p. 209-212

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PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.
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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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