New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata

Toshiro NOSHITA; Hiromasa KIYOTA; Yumi KIDACHI; Kazuo RYOYAMA; Shinji FUNAYAMA; Ken HANADA; Tetsuya MURAYAMA

doi:10.1271/bbb.80597

Organic Chemistry Notes

New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata

Toshiro NOSHITA, Hiromasa KIYOTA, Yumi KIDACHI, Kazuo RYOYAMA, Shinji FUNAYAMA, Ken HANADA, Tetsuya MURAYAMA

Author information

Keywords: Magnolia denudata, benzofuranone, denudalide, denudaquinol, cytotoxic metabolite

JOURNAL FREE ACCESS

2009 Volume 73 Issue 3 Pages 726-728

DOI https://doi.org/10.1271/bbb.80597

View "Advance Publication" version (March 7, 2009).

Details

Abstract

Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

Corresponding author

Register with J-STAGE for free!