New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata

Toshiro NOSHITA; Hiromasa KIYOTA; Yumi KIDACHI; Kazuo RYOYAMA; Shinji FUNAYAMA; Ken HANADA; Tetsuya MURAYAMA

doi:10.1271/bbb.80597

This article has now been updated. Please use the final version.

New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata

Toshiro NOSHITA, Hiromasa KIYOTA, Yumi KIDACHI, Kazuo RYOYAMA, Shinji FUNAYAMA, Ken HANADA, Tetsuya MURAYAMA

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Keywords: Magnolia denudata, benzofuranone, denudalide, denudaquinol, cytotoxic metabolite

JOURNAL FREE ACCESS Advance online publication

Article ID: 80597

DOI https://doi.org/10.1271/bbb.80597

The final version of this article is now available: Vol. 73 (2009) , No. 3 p.726

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Abstract

Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

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