New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata

Toshiro NOSHITA; Hiromasa KIYOTA; Yumi KIDACHI; Kazuo RYOYAMA; Shinji FUNAYAMA; Ken HANADA; Tetsuya MURAYAMA

doi:10.1271/bbb.80597

Organic Chemistry Notes

New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata

Toshiro NOSHITA, Hiromasa KIYOTA, Yumi KIDACHI, Kazuo RYOYAMA, Shinji FUNAYAMA, Ken HANADA, Tetsuya MURAYAMA

著者情報

キーワード: Magnolia denudata, benzofuranone, denudalide, denudaquinol, cytotoxic metabolite

ジャーナルフリー

2009 年 73 巻 3 号 p. 726-728

DOI https://doi.org/10.1271/bbb.80597

View "Advance Publication" version (March 7, 2009).

詳細

抄録

Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

責任著者(Corresponding author)

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