Identification of Ecl Family Genes That Extend Chronological Lifespan in Fission Yeast

抄録

In fission yeast, we identified two genes, named ecl2⁺ and ecl3⁺, that are paralogous to ecl1⁺, which extends the chronological lifespan. Both ecl2⁺ and ecl3⁺ extend the chronological lifespan when overexpressed as ecl1⁺. ecl2⁺ and ecl3⁺ encode 84- and 89-amino acid polypeptides respectively that are not annotated in the current database. The Ecl2 protein is localized mainly in the nucleus, as Ecl1. These results suggest that ecl1⁺, ecl2⁺, and ecl3⁺ have overlapping functions in the regulation of chronological lifespan.