The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Yumi KIDACHI; Toshiro NOSHITA; Hideaki YAMAGUCHI; Hironori UMETSU; Yoko FUKE; Kazuo RYOYAMA

doi:10.1271/bbb.80791

Food & Nutrition Science Notes

The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Yumi KIDACHI, Toshiro NOSHITA, Hideaki YAMAGUCHI, Hironori UMETSU, Yoko FUKE, Kazuo RYOYAMA

Author information

Keywords: 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC), glutathione, gamma-glutamylcysteine ligase gene, thiol compounds, Wasabia japonica

JOURNAL FREE ACCESS

2009 Volume 73 Issue 6 Pages 1419-1421

DOI https://doi.org/10.1271/bbb.80791

View "Advance Publication" version (June 7, 2009).

Details

Abstract

We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.

Corresponding author

Register with J-STAGE for free!