Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells
Yuriko YAMAOKAKenji OHGUCHITomohiro ITOHYoshinori NOZAWAYukihiro AKAO
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2009 Volume 73 Issue 6 Pages 1429-1431

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Abstract

In this study, we examined the effects of theaflavins, polyphenols in black tea, on α melanocyte-stimulating hormone (αMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3′-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.

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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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