Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells

Yuriko YAMAOKA; Kenji OHGUCHI; Tomohiro ITOH; Yoshinori NOZAWA; Yukihiro AKAO

doi:10.1271/bbb.80880

Food & Nutrition Science Notes

Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells

Yuriko YAMAOKA, Kenji OHGUCHI, Tomohiro ITOH, Yoshinori NOZAWA, Yukihiro AKAO

Author information

Keywords: melanin, melanogenesis, tyrosinase, theaflavins, black tea

JOURNAL FREE ACCESS

2009 Volume 73 Issue 6 Pages 1429-1431

DOI https://doi.org/10.1271/bbb.80880

View "Advance Publication" version (June 7, 2009).

Details

Abstract

In this study, we examined the effects of theaflavins, polyphenols in black tea, on α melanocyte-stimulating hormone (αMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3′-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.

Corresponding author

Register with J-STAGE for free!