The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Yumi KIDACHI; Toshiro NOSHITA; Hideaki YAMAGUCHI; Hironori UMETSU; Yoko FUKE; Kazuo RYOYAMA

doi:10.1271/bbb.80791

Food & Nutrition Science Notes

The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Yumi KIDACHI, Toshiro NOSHITA, Hideaki YAMAGUCHI, Hironori UMETSU, Yoko FUKE, Kazuo RYOYAMA

著者情報

キーワード: 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC), glutathione, gamma-glutamylcysteine ligase gene, thiol compounds, Wasabia japonica

ジャーナルフリー

2009 年 73 巻 6 号 p. 1419-1421

DOI https://doi.org/10.1271/bbb.80791

View "Advance Publication" version (June 7, 2009).

詳細

抄録

We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.

責任著者(Corresponding author)

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