The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Yumi KIDACHI; Toshiro NOSHITA; Hideaki YAMAGUCHI; Hironori UMETSU; Yoko FUKE; Kazuo RYOYAMA

doi:10.1271/bbb.80791

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The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Yumi KIDACHI, Toshiro NOSHITA, Hideaki YAMAGUCHI, Hironori UMETSU, Yoko FUKE, Kazuo RYOYAMA

著者情報

キーワード: 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC), glutathione, gamma-glutamylcysteine ligase gene, thiol compounds, Wasabia japocica

ジャーナルフリー早期公開

論文ID: 80791

DOI https://doi.org/10.1271/bbb.80791

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 6 p.1419

詳細

抄録

We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC).
Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression.
Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.

責任著者(Corresponding author)

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