Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Notes
The Hydrophobicity in a Chemically Modified Side-Chain of Cysteine Residues of Thanatin Is Related to Antimicrobial Activity against Micrococcus luteus
Yoshitake ORIKASAKenta ICHINOHEJunki SAITOShigeki HASHIMOTOKen’ichiro MATSUMOTOToshihiko OOISeiichi TAGUCHI
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2009 Volume 73 Issue 7 Pages 1683-1684

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Abstract

The chemically modified thanatins with the methyl group (CH3), ethyl group (C2H5), and normal-octyl group (C8H17) at the side-chain of cysteine residues were synthesized. The octyl group modified form exhibited 8-fold higher antimicrobial activity against Micrococcus luteus than wild type thanatin. It was found that there was an equilateral correlation between antimicrobial activity and side-chain hydrophobicity at the cysteine residues in thanatin.

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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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