Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO; Yuko KOBAYASHI; Harumi SATO; Atsushi HATTORI; Hiroaki TAKEUCHI; Keiichiro SUGIMOTO; Munekazu SHIGEKAWA

doi:10.1271/bbb.90205

Food & Nutrition Science Notes

Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO, Yuko KOBAYASHI, Harumi SATO, Atsushi HATTORI, Hiroaki TAKEUCHI, Keiichiro SUGIMOTO, Munekazu SHIGEKAWA

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Keywords: mast cell, degranulation, passive cutaneous anaphylaxis, anti-allergic effect, guarana

JOURNAL FREE ACCESS

2009 Volume 73 Issue 9 Pages 2110-2112

DOI https://doi.org/10.1271/bbb.90205

View "Advance Publication" version (September 7, 2009).

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Abstract

This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.

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