Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO; Yuko KOBAYASHI; Harumi SATO; Atsushi HATTORI; Hiroaki TAKEUCHI; Keiichiro SUGIMOTO; Munekazu SHIGEKAWA

doi:10.1271/bbb.90205

This article has now been updated. Please use the final version.

Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO, Yuko KOBAYASHI, Harumi SATO, Atsushi HATTORI, Hiroaki TAKEUCHI, Keiichiro SUGIMOTO, Munekazu SHIGEKAWA

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Keywords: mast cell, degranulation, passive cutaneous anaphylaxis, anti-allergic effect, guarana

JOURNAL FREE ACCESS Advance online publication

Article ID: 90205

DOI https://doi.org/10.1271/bbb.90205

The final version of this article is now available: Vol. 73 (2009) , No. 9 p.2110

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Abstract

This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.

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