Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO; Yuko KOBAYASHI; Harumi SATO; Atsushi HATTORI; Hiroaki TAKEUCHI; Keiichiro SUGIMOTO; Munekazu SHIGEKAWA

doi:10.1271/bbb.90205

Food & Nutrition Science Notes

Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO, Yuko KOBAYASHI, Harumi SATO, Atsushi HATTORI, Hiroaki TAKEUCHI, Keiichiro SUGIMOTO, Munekazu SHIGEKAWA

著者情報

キーワード: mast cell, degranulation, passive cutaneous anaphylaxis, anti-allergic effect, guarana

ジャーナルフリー

2009 年 73 巻 9 号 p. 2110-2112

DOI https://doi.org/10.1271/bbb.90205

View "Advance Publication" version (September 7, 2009).

詳細

抄録

This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.

責任著者(Corresponding author)

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