Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO; Yuko KOBAYASHI; Harumi SATO; Atsushi HATTORI; Hiroaki TAKEUCHI; Keiichiro SUGIMOTO; Munekazu SHIGEKAWA

doi:10.1271/bbb.90205

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Inhibitory Effects of Guarana Seed Extract on Passive Cutaneous Anaphylaxis and Mast Cell Degranulation

Tomoko JIPPO, Yuko KOBAYASHI, Harumi SATO, Atsushi HATTORI, Hiroaki TAKEUCHI, Keiichiro SUGIMOTO, Munekazu SHIGEKAWA

著者情報

キーワード: mast cell, degranulation, passive cutaneous anaphylaxis, anti-allergic effect, guarana

ジャーナルフリー早期公開

論文ID: 90205

DOI https://doi.org/10.1271/bbb.90205

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 9 p.2110

詳細

抄録

This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.

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