Fast and Reliable Determination of Voriconazole in Human Plasma by LC-APCI-MS/MS

Xin XIONG; Jingli DUAN; Suodi ZHAI; Lijue WANG; Xi LAN

doi:10.1271/bbb.100474

Analytical Chemistry Note

Fast and Reliable Determination of Voriconazole in Human Plasma by LC-APCI-MS/MS

Xin XIONG, Jingli DUAN, Suodi ZHAI, Lijue WANG, Xi LAN

Author information

Keywords: voriconazole, liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS), human plasma

JOURNAL FREE ACCESS

2010 Volume 74 Issue 10 Pages 2151-2153

DOI https://doi.org/10.1271/bbb.100474

View "Advance Publication" version (October 7, 2010).

Details

Abstract

A fast and reliable liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method was developed and validated for the quantification of voriconazole in human plasma. The proposed method was validated in a linear range of 50–10,000 ng/ml, and the total run time was 1.5 min. This method was successfully used to support routine therapeutic drug monitoring of voriconazole.

Corresponding author

Register with J-STAGE for free!