Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI; Koichiro SATO; Tatsuya KIBE; Hiroyuki SEIMIYA; Asako NAKAMURA; Masashi YUKAWA; Eiko TSUCHIYA; Masaru UENO

doi:10.1271/bbb.90496

Biochemistry & Molecular Biology Notes

Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI, Koichiro SATO, Tatsuya KIBE, Hiroyuki SEIMIYA, Asako NAKAMURA, Masashi YUKAWA, Eiko TSUCHIYA, Masaru UENO

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Keywords: replication protein A, telomere, human cancer cells

JOURNAL FREE ACCESS

2010 Volume 74 Issue 2 Pages 382-385

DOI https://doi.org/10.1271/bbb.90496

View "Advance Publication" version (February 7, 2010).

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Abstract

Replication protein A (RPA) binds to single-stranded DNA generated during DNA replication and other processes. The roles of RPA in telomere maintenance have been demonstrated in yeasts, but not in telomerase-positive human cells. In this study, we found that expression of mutant RPA70 in human cells caused telomere shortening, suggesting that RPA is required for telomere-length regulation in human cancer cells.

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