Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI; Koichiro SATO; Tatsuya KIBE; Hiroyuki SEIMIYA; Asako NAKAMURA; Masashi YUKAWA; Eiko TSUCHIYA; Masaru UENO

doi:10.1271/bbb.90496

This article has now been updated. Please use the final version.

Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI, Koichiro SATO, Tatsuya KIBE, Hiroyuki SEIMIYA, Asako NAKAMURA, Masashi YUKAWA, Eiko TSUCHIYA, Masaru UENO

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Keywords: replication protein A, telomere, human cancer cells

JOURNAL FREE ACCESS Advance online publication

Article ID: 90496

DOI https://doi.org/10.1271/bbb.90496

The final version of this article is now available: Vol. 74 (2010) , No. 2 p.382

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Abstract

Replication protein A (RPA) binds to single-stranded DNA generated during DNA replication and other processes. The roles of RPA in telomere maintenance have been demonstrated in yeasts, but not in telomerase-positive human cells. In this study, we found that expression of mutant RPA70 in human cells caused telomere shortening, suggesting that RPA is required for telomere-length regulation in human cancer cells.

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