Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI; Koichiro SATO; Tatsuya KIBE; Hiroyuki SEIMIYA; Asako NAKAMURA; Masashi YUKAWA; Eiko TSUCHIYA; Masaru UENO

doi:10.1271/bbb.90496

Biochemistry & Molecular Biology Notes

Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI, Koichiro SATO, Tatsuya KIBE, Hiroyuki SEIMIYA, Asako NAKAMURA, Masashi YUKAWA, Eiko TSUCHIYA, Masaru UENO

著者情報

キーワード: replication protein A, telomere, human cancer cells

ジャーナルフリー

2010 年 74 巻 2 号 p. 382-385

DOI https://doi.org/10.1271/bbb.90496

View "Advance Publication" version (February 7, 2010).

詳細

抄録

Replication protein A (RPA) binds to single-stranded DNA generated during DNA replication and other processes. The roles of RPA in telomere maintenance have been demonstrated in yeasts, but not in telomerase-positive human cells. In this study, we found that expression of mutant RPA70 in human cells caused telomere shortening, suggesting that RPA is required for telomere-length regulation in human cancer cells.

責任著者(Corresponding author)

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